Resultados da pesquisa - (( a small compound mouse new ) OR ((( j (nal OR nayla) clamp a non ) OR ( j narr cam _ non ))))

Pesquisas alternativas:
compound mouse » compound mode (Expandir a Pesquisa), compound more (Expandir a Pesquisa), compound use (Expandir a Pesquisa)
mouse new » house new (Expandir a Pesquisa), use new (Expandir a Pesquisa), mouse nih (Expandir a Pesquisa)
narr cam » arr cam (Expandir a Pesquisa), narr c (Expandir a Pesquisa)
clamp a » clamp _ (Expandir a Pesquisa), clamp j (Expandir a Pesquisa)
j narr » l narr (Expandir a Pesquisa), j nair (Expandir a Pesquisa), j nasr (Expandir a Pesquisa)

1

Novel patient-derived xenograft mouse model for pancreatic acinar cell carcinoma demonstrates single agent activity of oxaliplatin

Novel patient-derived xenograft mouse model for pancreatic acinar cell carcinoma demonstrates single agent activity of oxaliplatin

Por Hall, Jason C., Marlow, Laura A., Mathias, Adam C., Dawson, Louis K., Durham, William F., Meshaw, Kenneth A., Mullin, Robert J., Synnott, Aidan J., Small, Daniel L., Krishna, Murli, von Hoff, Daniel, Schüler, Julia, Hart, Steven N., Couch, Fergus J., Colon-Otero, Gerardo, Copland, John A.
Publicado no J Transl Med (2016)

“... PDTX model. Here we show sustained anti-tumor activity of single agent oxaliplatin, a compound...”
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2

A Novel Approach to Screening for New Neuroprotective Compounds for the Treatment of Stroke

A Novel Approach to Screening for New Neuroprotective Compounds for the Treatment of Stroke

Por Maher, Pamela, Salgado, Karmen. F., Zivin, Justin A., Lapchak, Paul A.
Publicado em 2007

“... compounds that might be effective, we have developed a cell culture-based assay with death being an endpoint...”
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3

Transcriptional inhibitors identified in a 160,000-compound small molecule DUX4-viability screen

Transcriptional inhibitors identified in a 160,000-compound small molecule DUX4-viability screen

Por Choi, Si Ho, Bosnakovski, Darko, Strasser, Jessica M., Toso, Erik A., Walters, Michael A., Kyba, Michael
Publicado no J Biomol Screen (2016)

“... screen based on Tet-on DUX4-induced mouse myoblast death previously uncovered compounds from a 44,000...”
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4

Compound mouse mutants of bZIP transcription factors Mafg and Mafk reveal a regulatory network of non-crystallin genes associated with cataract

Compound mouse mutants of bZIP transcription factors Mafg and Mafk reveal a regulatory network of non-crystallin genes associated with cataract

Por Agrawal, Smriti A., Anand, Deepti, Siddam, Archana D., Kakrana, Atul, Dash, Soma, Scheiblin, David A., Dang, Christine A., Terrell, Anne M., Waters, Stephanie M., Singh, Abhyudai, Motohashi, Hozumi, Yamamoto, Masayuki, Lachke, Salil A.
Publicado no Hum Genet (2015)

“... a detailed small Maf regulatory network in the lens, several nodes of which are linked to cataract...”
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5

Identification of a Small Molecule That Selectively Inhibits Mouse PC2 over Mouse PC1/3: A Computational and Experimental Study

Identification of a Small Molecule That Selectively Inhibits Mouse PC2 over Mouse PC1/3: A Computational and Experimental Study

Por Yongye, Austin B., Vivoli, Mirella, Lindberg, Iris, Appel, Jon R., Houghten, Richard A., Martinez-Mayorga, Karina
Publicado em 2013

“... the Maybridge small molecule library towards mouse PC2. Our most remarkable finding was the identification of a...”
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6

Amino acid absorption by mouse ascites-tumour cells depleted of both endogenous amino acids and adenosine triphosphate

Amino acid absorption by mouse ascites-tumour cells depleted of both endogenous amino acids and adenosine triphosphate

Por Morville, M., Reid, M., Eddy, A. A.
Publicado em 1973

“... by the spontaneous flow of Na(+) ions into the cellular phase. Dependent on (a) which compound was used, (b) its...”
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7

(3-Cyano-5-fluorophenyl)biaryl Negative Allosteric Modulators of mGlu(5): Discovery of a New Tool Compound with Activity in the OSS Mouse Model of Addiction

(3-Cyano-5-fluorophenyl)biaryl Negative Allosteric Modulators of mGlu(5): Discovery of a New Tool Compound with Activity in the OSS Mouse Model of Addiction

Por Lindsley, Craig W., Bates, Brittney S., Menon, Usha N., Jadhav, Satyawan B., Kane, Alexander S., Jones, Carrie K., Rodriguez, Alice L., Conn, P. Jeffrey, Olsen, Christopher M., Winder, Danny G., Emmitte, Kyle A.
Publicado em 2011

“.... The compound was efficacious in a mouse marble burying model of anxiety, an assay known to be sensitive to mGlu...”
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8

Enhancement of SMN protein levels in a mouse model of spinal muscular atrophy using novel drug-like compounds

Enhancement of SMN protein levels in a mouse model of spinal muscular atrophy using novel drug-like compounds

Por Cherry, Jonathan J, Osman, Erkan Y, Evans, Matthew C, Choi, Sungwoon, Xing, Xuechao, Cuny, Gregory D, Glicksman, Marcie A, Lorson, Christian L, Androphy, Elliot J
Publicado em 2013

“... from the endogenous SMN2 gene should lessen disease severity. We have developed and implemented a new...”
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9

In vitro and in vivo effects of the conformationally restricted polyamine analogue CGC-11047 on small cell and non-small cell lung cancer cells

In vitro and in vivo effects of the conformationally restricted polyamine analogue CGC-11047 on small cell and non-small cell lung cancer cells

Por Hacker, Amy, Marton, Laurence J., Sobolewski, Michelle, Casero, Robert A.
Publicado em 2008

“... limited by apparent toxicity. A representative compound of a new generation of short chain...”
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10

Tumor-targeted SN38 inhibits growth of early stage non-small cell lung cancer (NSCLC) in a KRas/p53 transgenic mouse model

Tumor-targeted SN38 inhibits growth of early stage non-small cell lung cancer (NSCLC) in a KRas/p53 transgenic mouse model

Por Deneka, Alexander Y., Haber, Leora, Kopp, Meghan C., Gaponova, Anna V., Nikonova, Anna S., Golemis, Erica A.
Publicado no PLoS One (2017)

“...Non-small cell lung cancer (NSCLC) is the leading cause of cancer death worldwide, with a 5-year...”
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11

Genomic Analysis of the Nuclear Receptor Family: New Insights Into Structure, Regulation, and Evolution From the Rat Genome

Genomic Analysis of the Nuclear Receptor Family: New Insights Into Structure, Regulation, and Evolution From the Rat Genome

Por Zhang, Zhengdong, Burch, Paula E., Cooney, Austin J., Lanz, Rainer B., Pereira, Fred A., Wu, Jiaqian, Gibbs, Richard A., Weinstock, George, Wheeler, David A.
Publicado em 2004

“...Completion of the Rattus norvegicus genome sequence enabled a global inventory and analysis...”
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12

Small Molecule MRP1 Inhibitor Reversan Increases the Therapeutic Index of Chemotherapy in Mouse Model of Neuroblastoma

Small Molecule MRP1 Inhibitor Reversan Increases the Therapeutic Index of Chemotherapy in Mouse Model of Neuroblastoma

Por Burkhart, Catherine A., Watt, Fujiko, Murray, Jayne, Pajic, Marina, Prokvolit, Anatoly, Xue, Chengyuan, Flemming, Claudia, Smith, Janice, Purmal, Andrei, Isachenko, Nadezhda, Komarov, Pavel G., Gurova, Katerina V., Sartorelli, Alan C., Marshall, Glenn M., Norris, Murray D., Gudkov, Andrei V., Haber, Michelle
Publicado em 2009

“.... Therefore, Reversan represents a new class of non-toxic MRP1 inhibitor, which may be clinically useful...”
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13

Phenotypic assays identify a small molecule modulator of the unfolded protein response with anti-diabetic activity

Phenotypic assays identify a small molecule modulator of the unfolded protein response with anti-diabetic activity

Por Fu, S., Yalcin, A., Lee, G.Y., Li, P., Fan, Jason, Arruda, A.P., Pers, B.M., Yilmaz, M., Eguchi, K., Hotamisligil, G.S.
Publicado no Sci Transl Med (2015)

“... of ER. With these quantitative platforms, we characterized a small molecule compound, azoromide...”
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14

Relaxing Effect of TSU-68, an Antiangiogenic Agent, on Mouse Airway Smooth Muscle

Relaxing Effect of TSU-68, an Antiangiogenic Agent, on Mouse Airway Smooth Muscle

Por Honghao Tan, Jun Lei, Lu Xue, Congli Cai, Qing-hua Liu, Jinhua Shen
Publicado em 2017-04-01

Assuntos: “...Small-molecule chemical compound...”
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15

PET Imaging Demonstrates Histone Deacetylase Target Engagement and Clarifies Brain Penetrance of Known and Novel Small Molecule Inhibitors in Rat

PET Imaging Demonstrates Histone Deacetylase Target Engagement and Clarifies Brain Penetrance of Known and Novel Small Molecule Inhibitors in Rat

Por Schroeder, F. A., Wang, C., Van de Bittner, G. C., Neelamegam, R., Takakura, W. R., Karunakaran, A., Wey, H. Y., Reis, S. A., Gale, J., Zhang, Y. L., Holson, E. B., Haggarty, S. J., Hooker, J. M.
Publicado em 2014

“... highlights a new translational path for understanding the molecular and behavioral consequences of HDAC...”
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16

A Focused Small-Molecule Screen Identifies 14 Compounds with Distinct Effects on Toxoplasma gondii

A Focused Small-Molecule Screen Identifies 14 Compounds with Distinct Effects on Toxoplasma gondii

Por Kamau, Edwin T., Srinivasan, Ananth R., Brown, Mark J., Fair, Matthew G., Caraher, Erin J., Boyle, Jon P.
Publicado em 2012

“... compound proved potent. Overall, these 14 compounds represent a new and diverse set of small molecules...”
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17

A small-molecule antivirulence agent for treating Clostridium difficile infection

A small-molecule antivirulence agent for treating Clostridium difficile infection

Por Bender, Kristina Oresic, Garland, Megan, Ferreyra, Jessica A., Hryckowian, Andrew J., Child, Matthew A., Puri, Aaron W., Solow-Cordero, David E., Higginbottom, Steven K., Segal, Ehud, Banaei, Niaz, Shen, Aimee, Sonnenburg, Justin L., Bogyo, Matthew
Publicado no Sci Transl Med (2015)

“... one bioactive compound, ebselen, which is currently in human clinical trials for a clinically...”
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18

A Small Molecule Screen in Stem Cell-derived Motor Neurons Identifies a Kinase Inhibitor as a Candidate Therapeutic for ALS

A Small Molecule Screen in Stem Cell-derived Motor Neurons Identifies a Kinase Inhibitor as a Candidate Therapeutic for ALS

Por Yang, Yin M., Gupta, Shailesh K., Kim, Kevin J., Powers, Berit E., Cerqueira, Antonio, Wainger, Brian J., Ngo, Hien D., Rosowski, Kathryn A., Schein, Pamela A., Ackeifi, Courtney A., Arvanites, Anthony C., Davidow, Lance S., Woolf, Clifford J., Rubin, Lee L.
Publicado em 2013

“... new small molecule survival screen carried out using MNs from both wildtype and mutant SOD1 mouse...”
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19

Double-Stranded RNA-Dependent Protein Kinase-Dependent Apoptosis
Induction by a Novel Small
Compound

Double-Stranded RNA-Dependent Protein Kinase-Dependent Apoptosis Induction by a Novel Small Compound

Por Hu, Wenxian, Hofstetter, Wayne, Wei, Xiaoli, Guo, Wei, Zhou, Yanbin, Pataer, Abujiang, Li, Hong, Fang, Bingliang, Swisher, Stephen G.
Publicado em 2009

“...(+/+)] and PKR-knockout [MEF/PKR(-/-)] mouse embryonic fibroblast cells. We identified a synthetic compound, BEPP...”
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20

Aryl Phosphoramidates of 5-Phospho Erythronohydroxamic Acid, A New Class of Potent Trypanocidal Compounds

Aryl Phosphoramidates of 5-Phospho Erythronohydroxamic Acid, A New Class of Potent Trypanocidal Compounds

Por Ruda, Gian Filippo, Wong, Pui Ee, Alibu, Vincent P., Norval, Suzanne, Read, Kevin D., Barrett, Michael P., Gilbert, Ian H.
Publicado em 2010

“... prodrugs of 2,3-O-isopropylidene-4-erythrono hydroxamate by synthesizing a small library...”
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