Small Molecule MRP1 Inhibitor Reversan Increases the Therapeutic Index of Chemotherapy in Mouse Model of Neuroblastoma

The multidrug resistance-associated protein (MRP1) has been closely linked to poor treatment response in several cancers, most notably neuroblastoma. Homozygous deletion of the MRP1 gene in primary murine neuroblastoma tumors resulted in increased sensitivity to MRP1 substrate drugs (vincristine, et...

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Detalhes bibliográficos
Main Authors: Burkhart, Catherine A., Watt, Fujiko, Murray, Jayne, Pajic, Marina, Prokvolit, Anatoly, Xue, Chengyuan, Flemming, Claudia, Smith, Janice, Purmal, Andrei, Isachenko, Nadezhda, Komarov, Pavel G., Gurova, Katerina V., Sartorelli, Alan C., Marshall, Glenn M., Norris, Murray D., Gudkov, Andrei V., Haber, Michelle
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2746061/
https://ncbi.nlm.nih.gov/pubmed/19654298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-1075
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