Relationship between the induction of leukemia cell differentiation and the enhancement of reporter gene expression in 3T3 Swiss cells

Por Ishiguro, Kimiko, Sartorelli, Alan C.
Publicado em 2007

Pharmacological and genetic modulation of Wnt-targeted Cre-Lox-mediated gene expression in colorectal cancer cells

Por Bordonaro, Michael, Lazarova, Darina L., Sartorelli, Alan C.
Publicado em 2004

PARP Inhibitors: On the Horizon of Tailored and Personalized Therapies for Epithelial Ovarian Cancer

Por Ratner, Elena S., Sartorelli, Alan C., Lin, Z. Ping
Publicado em 2012

The Activation of Beta-Catenin by Wnt Signaling Mediates the Effects of Histone Deacetylase Inhibitors

Por Bordonaro, Michael, Lazarova, Darina L., Sartorelli, Alan C.
Publicado em 2007

ALTERATIONS IN CELLULAR METABOLISM ASSOCIATED WITH CELL DEATH INDUCED BY URACIL MUSTARD AND 6-THIOGUANINE

Por Booth, Barbara A., Creasey, William A., Sartorelli, Alan C.
Publicado em 1964

Development of an O(6)-alkylguanine—DNA alkyltransferase assay based on covalent transfer of the benzyl moiety from [benzene-(3)H]O(6)-benzylguanine to the protein

Por Ishiguro, Kimiko, Shyam, Krishnamurthy, Penketh, Philip G., Sartorelli, Alan C.
Publicado em 2008

Inhibition of all-trans retinoic acid-induced granulocytic differentiation of WEHI-3B D(+) cells by forced expression of SCL (TAL1) and GATA-1

Por Ishiguro, Kimiko, Rice, Anna M., Rice, Kevin P., Sartorelli, Alan C.
Publicado em 2009

1,2-Bis(methylsulfonyl)-1-(2-chloroethyl)-2-[[1-(4-nitrophenyl)ethoxy]carbonyl]hydrazine: An anticancer agent targeting hypoxic cells

Por Seow, Helen A., Penketh, Philip G., Shyam, Krishnamurthy, Rockwell, Sara, Sartorelli, Alan C.
Publicado em 2005

Ataxia-telangiectasia mutated kinase regulates ribonucleotide reductase and mitochondrial homeostasis

Por Eaton, Jana S., Lin, Z. Ping, Sartorelli, Alan C., Bonawitz, Nicholas D., Shadel, Gerald S.
Publicado em 2007

Mode of action of the chloroethylating and carbamoylating moieties of the prodrug cloretazine

Por Ishiguro, Kimiko, Seow, Helen A., Penketh, Philip G., Shyam, Krishnamurthy, Sartorelli, Alan C.
Publicado em 2006

Hypoxia-selective O(6)-Alkylguanine-DNA Alkyltransferase Inhibitors: Design, Synthesis and Evaluation of 6-(Benzyloxy)-2-(aryldiazenyl)-9H-purines as Prodrugs of O(6)-Benzylguanine

Por Zhu, Rui, Baumann, Raymond P., Penketh, Philip G., Shyam, Krishnamurthy, Sartorelli, Alan C.
Publicado em 2013

Triapine Disrupts CtIP-mediated Homologous Recombination Repair and Sensitizes Ovarian Cancer Cells to PARP and Topoisomerase Inhibitors

Por Lin, Z. Ping, Ratner, Elena S., Whicker, Margaret E., Lee, Yashang, Sartorelli, Alan C.
Publicado em 2014

MK-2206 sensitizes BRCA-deficient epithelial ovarian adenocarcinoma to cisplatin and olaparib

Por Whicker, Margaret E., Lin, Z. Ping, Hanna, Ruth, Sartorelli, Alan C., Ratner, Elena S.
Publicado no BMC Cancer (2016)

Generation of Oxygen Deficiency in Cell Culture Using a Two-Enzyme System to Evaluate Agents Targeting Hypoxic Tumor Cells

Por Baumann, Raymond P., Penketh, Philip G., Seow, Helen A., Shyam, Krishnamurthy, Sartorelli, Alan C.
Publicado em 2008

Overexpression of heat shock factor 1 inhibits butyrate-induced differentiation in colon cancer cells

Por Cai, Jiyang, Kirlin, Ward G., Chen, Yan, Yan, Xuexian, Jones, Dean P., Sartorelli, Alan C.
Publicado em 2006

KS900: a hypoxia-directed, reductively activated methylating antitumor prodrug that selectively ablates O(6)-alkylguanine-DNA alkyltransferase in neoplastic cells

Por Baumann, Raymond P., Ishiguro, Kimiko, Penketh, Philip G., Shyam, Krishnamurthy, Zhu, Rui, Sartorelli, Alan C.
Publicado em 2011

Influence of Phosphate and Phosphoesters on the Decomposition Pathway of 1,2-Bis(methylsulfonyl)-1-(2-chloroethyhydrazine (90CE), the Active Anticancer Moiety Generated by Laromust...

Por Penketh, Philip G., Shyam, Krishnamurthy, Zhu, Rui, Baumann, Raymond P., Ishiguro, Kimiko, Sartorelli, Alan C.
Publicado em 2014

Reductive activation of the prodrug 1,2-bis(methylsulfonyl)-1-(2-chloroethyl)-2-[[1-(4-nitrophenyl)ethoxy]carbonyl]hydrazine (KS119) selectively occurs in oxygen-deficient cells an...

Por Baumann, Raymond P., Penketh, Philip G., Ishiguro, Kimiko, Shyam, Krishnamurthy, Zhu, Yong L., Sartorelli, Alan C.
Publicado em 2009

Lethality to leukemia cell lines of DNA interstrand cross-links generated by Cloretazine derived alkylating species

Por Penketh, Philip G., Baumann, Raymond P., Ishiguro, Kimiko, Shyam, Krishnamurthy, Seow, Helen A., Sartorelli, Alan C.
Publicado em 2008

Structure and Function Converge To Identify a Hydrogen Bond in a Group I Ribozyme Active Site

Por Forconi, Marcello, Sengupta, Raghuvir N., Liu, Mao-Chin, Sartorelli, Alan C., Piccirilli, Joseph A., Herschlag, Daniel
Publicado em 2009