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The Activation of Beta-Catenin by Wnt Signaling Mediates the Effects of Histone Deacetylase Inhibitors

Most colorectal carcinomas (CRCs) exhibit constitutively active Wnt signaling. We have reported that (a) the histone deacetylase inhibitor (HDACi)() sodium butyrate (NaB) modulates the canonical Wnt transcriptional activity of CRC cells in vitro and (b) a linear relationship exists between the incre...

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Bibliographic Details
Main Authors: Bordonaro, Michael, Lazarova, Darina L., Sartorelli, Alan C.
Format: Artigo
Language:Inglês
Published: 2007
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3919021/
https://ncbi.nlm.nih.gov/pubmed/17359971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yexcr.2007.02.008
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