CBP Activity Mediates Effects of the Histone Deacetylase Inhibitor Butyrate on WNT Activity and Apoptosis in Colon Cancer Cells

Mutations in the WNT/beta-catenin pathway are responsible for initiating the majority of colorectal cancers (CRCs). We have previously shown that hyperactivation of this signaling by histone deacetylase inhibitors (HDACis) such as butyrate, a fermentation product of dietary fiber, promotes CRC cell...

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Autori principali: Lazarova, Darina L, Chiaro, Christopher, Wong, Terrence, Drago, Eric, Rainey, Anthony, O'Malley, Shannon, Bordonaro, Michael
Natura: Artigo
Lingua:Inglês
Pubblicazione: Ivyspring International Publisher 2013
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3726710/
https://ncbi.nlm.nih.gov/pubmed/23901348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/jca.6583
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