Influence of Phosphate and Phosphoesters on the Decomposition Pathway of 1,2-Bis(methylsulfonyl)-1-(2-chloroethyhydrazine (90CE), the Active Anticancer Moiety Generated by Laromustine, KS119, and KS119W

[Image: see text] Prodrugs of the short-lived chloroethylating agent 1,2-bis(methylsulfonyl)-1-(2-chloroethyl)hydrazine (90CE) and its methylating analogue 1,2-bis(methylsulfonyl)-1-(methyl)hydrazine (KS90) are potentially useful anticancer agents. This class of agents frequently yields higher ratio...

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Autores principales: Penketh, Philip G., Shyam, Krishnamurthy, Zhu, Rui, Baumann, Raymond P., Ishiguro, Kimiko, Sartorelli, Alan C.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Chemical Society 2014
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4033638/
https://ncbi.nlm.nih.gov/pubmed/24618018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx500004y
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