Influence of Glutathione and Glutathione S-transferases on DNA Interstrand Cross-Link Formation by 1,2-Bis(methylsulfonyl)-1-(2-chloroethyl)hydrazine, the Active Anticancer Moiety Generated by Laromustine

[Image: see text] Prodrugs of 1,2-bis(methylsulfonyl)-1-(2-chloroethyl)hydrazine (90CE) are promising anticancer agents. The 90CE moiety is a readily latentiated, short-lived (t(1/2) ∼ 30 s) chloroethylating agent that can generate high yields of oxophilic electrophiles responsible for the chloroeth...

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Detalhes bibliográficos
Main Authors: Penketh, Philip G., Patridge, Eric, Shyam, Krishnamurthy, Baumann, Raymond P., Zhu, Rui, Ishiguro, Kimiko, Sartorelli, Alan C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4137992/
https://ncbi.nlm.nih.gov/pubmed/25012050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx500197t
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