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Influence of Glutathione and Glutathione S-transferases on DNA Interstrand Cross-Link Formation by 1,2-Bis(methylsulfonyl)-1-(2-chloroethyl)hydrazine, the Active Anticancer Moiety Generated by Laromustine
[Image: see text] Prodrugs of 1,2-bis(methylsulfonyl)-1-(2-chloroethyl)hydrazine (90CE) are promising anticancer agents. The 90CE moiety is a readily latentiated, short-lived (t(1/2) ∼ 30 s) chloroethylating agent that can generate high yields of oxophilic electrophiles responsible for the chloroeth...
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| Glavni autori: | , , , , , , |
|---|---|
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Chemical
Society
2014
|
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4137992/ https://ncbi.nlm.nih.gov/pubmed/25012050 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx500197t |
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