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Mode of action of the chloroethylating and carbamoylating moieties of the prodrug cloretazine
Cloretazine is an antitumor sulfonylhydrazine prodrug that generates both chloroethylating and carbamoylating species. The cytotoxic potency of these species was analyzed in L1210 leukemia cells using analogues with chloroethylating or carbamoylating function only. Clonogenic assays showed that the...
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| 主要な著者: | , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2006
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2680221/ https://ncbi.nlm.nih.gov/pubmed/16648568 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-05-0532 |
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