Design of a Hypoxia-Activated Prodrug Inhibitor of O(6)-Alkylguanine-DNA Alkyltransferase

Lignende værker

• KS900: a hypoxia-directed, reductively activated methylating antitumor prodrug that selectively ablates O(6)-alkylguanine-DNA alkyltransferase in neoplastic cells
  af: Baumann, Raymond P., et al.
  Udgivet: (2011)
• Hypoxia-selective O(6)-Alkylguanine-DNA Alkyltransferase Inhibitors: Design, Synthesis and Evaluation of 6-(Benzyloxy)-2-(aryldiazenyl)-9H-purines as Prodrugs of O(6)-Benzylguanine
  af: Zhu, Rui, et al.
  Udgivet: (2013)
• A strategy for selective O(6)-alkylguanine-DNA alkyltransferase depletion under hypoxic conditions
  af: Penketh, Philip G., et al.
  Udgivet: (2012)
• 4-Nitrobenzyloxycarbonyl Derivatives of O(6)-Benzylguanine as Hypoxia-Activated Prodrug Inhibitors of O(6)-Alkylguanine-DNA Alkyltransferase (AGT) which Produces Resistance to Agents Targeting the O-6 Position of DNA Guanine
  af: Zhu, Rui, et al.
  Udgivet: (2011)
• Quantitative relationship between guanine O(6)-alkyl lesions produced by Onrigin(™) and tumor resistance by O(6)-alkylguanine-DNA alkyltransferase
  af: Ishiguro, Kimiko, et al.
  Udgivet: (2010)