4-Nitrobenzyloxycarbonyl Derivatives of O(6)-Benzylguanine as Hypoxia-Activated Prodrug Inhibitors of O(6)-Alkylguanine-DNA Alkyltransferase (AGT) which Produces Resistance to Agents Targeting the O-6 Position of DNA Guanine

A series of 4-nitrobenzyloxycarbonyl prodrug derivatives of O(6)-benzylguanine (O(6)-BG), conceived as prodrugs of O(6)-BG, an inhibitor of the resistance protein O(6)-alkylguanine-DNA alkyltransferase (AGT), were synthesized and evaluated for their ability to undergo bioreductive activation by redu...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Zhu, Rui, Liu, Mao-Chin, Luo, Mei-Zhen, Penketh, Philip G., Baumann, Raymond P., Shyam, Krishnamurthy, Sartorelli, Alan C.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2011
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3220054/
https://ncbi.nlm.nih.gov/pubmed/21955333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm201115f
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