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Quantitative relationship between guanine O(6)-alkyl lesions produced by Onrigin(™) and tumor resistance by O(6)-alkylguanine-DNA alkyltransferase
O(6)-Alkylguanine-DNA alkyltransferase (AGT) mediates tumor resistance to alkylating agents that generate guanine O(6)-chloroethyl (Onrigin(™) and carmustine) and O(6)-methyl (temozolomide) lesions; however, the relative efficiency of AGT protection against these lesions and the degree of resistance...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2950702/ https://ncbi.nlm.nih.gov/pubmed/20654586 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2010.07.022 |
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