Quantitative relationship between guanine O(6)-alkyl lesions produced by Onrigin(™) and tumor resistance by O(6)-alkylguanine-DNA alkyltransferase

O(6)-Alkylguanine-DNA alkyltransferase (AGT) mediates tumor resistance to alkylating agents that generate guanine O(6)-chloroethyl (Onrigin(™) and carmustine) and O(6)-methyl (temozolomide) lesions; however, the relative efficiency of AGT protection against these lesions and the degree of resistance...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Ishiguro, Kimiko, Zhu, Yong-Lian, Shyam, Krishnamurthy, Penketh, Philip G., Baumann, Raymond P., Sartorelli, Alan C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
Schlagworte:
Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2950702/
https://ncbi.nlm.nih.gov/pubmed/20654586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2010.07.022
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge