Quantitative relationship between guanine O(6)-alkyl lesions produced by Onrigin(™) and tumor resistance by O(6)-alkylguanine-DNA alkyltransferase

O(6)-Alkylguanine-DNA alkyltransferase (AGT) mediates tumor resistance to alkylating agents that generate guanine O(6)-chloroethyl (Onrigin(™) and carmustine) and O(6)-methyl (temozolomide) lesions; however, the relative efficiency of AGT protection against these lesions and the degree of resistance...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Ishiguro, Kimiko, Zhu, Yong-Lian, Shyam, Krishnamurthy, Penketh, Philip G., Baumann, Raymond P., Sartorelli, Alan C.
Format: Artigo
Langue:Inglês
Publié: 2010
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2950702/
https://ncbi.nlm.nih.gov/pubmed/20654586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2010.07.022
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