A strategy for selective O(6)-alkylguanine-DNA alkyltransferase depletion under hypoxic conditions

Cellular resistance to chemotherapeutics that alkylate the O-6 position of guanine residues in DNA correlates with their O(6)-alkylguanine-DNA alkyltransferase (AGT) activity. In normal cells high [AGT] is benefical, sparing the host from toxicity, whereas in tumor cells high [AGT] prevents chemothe...

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Detalhes bibliográficos
Main Authors: Penketh, Philip G., Shyam, Krishnamurthy, Baumann, Raymond P., Ishiguro, Kimiko, Patridge, Eric V., Zhu, Rui, Sartorelli, Alan C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3399964/
https://ncbi.nlm.nih.gov/pubmed/22553921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1747-0285.2012.01401.x
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