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A strategy for selective O(6)-alkylguanine-DNA alkyltransferase depletion under hypoxic conditions
Cellular resistance to chemotherapeutics that alkylate the O-6 position of guanine residues in DNA correlates with their O(6)-alkylguanine-DNA alkyltransferase (AGT) activity. In normal cells high [AGT] is benefical, sparing the host from toxicity, whereas in tumor cells high [AGT] prevents chemothe...
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| Main Authors: | , , , , , , |
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| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
2012
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3399964/ https://ncbi.nlm.nih.gov/pubmed/22553921 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1747-0285.2012.01401.x |
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