A strategy for selective O(6)-alkylguanine-DNA alkyltransferase depletion under hypoxic conditions

Cellular resistance to chemotherapeutics that alkylate the O-6 position of guanine residues in DNA correlates with their O(6)-alkylguanine-DNA alkyltransferase (AGT) activity. In normal cells high [AGT] is benefical, sparing the host from toxicity, whereas in tumor cells high [AGT] prevents chemothe...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Penketh, Philip G., Shyam, Krishnamurthy, Baumann, Raymond P., Ishiguro, Kimiko, Patridge, Eric V., Zhu, Rui, Sartorelli, Alan C.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2012
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3399964/
https://ncbi.nlm.nih.gov/pubmed/22553921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1747-0285.2012.01401.x
Tagit: Lisää tagi
Ei tageja, Lisää ensimmäinen tagi!

Samankaltaisia teoksia