Lethality to leukemia cell lines of DNA interstrand cross-links generated by Cloretazine derived alkylating species

Cloretazine [1, 2-bis(methylsulfonyl)-1-(2-chloroethyl)-2-[(methylamino)carbonyl]-hydrazine; VNP40101M; 101M] is a relatively new prodrug with activity in elderly acute myelogenous leukemia patients. Its therapeutic action is due largely to the production of 1-(3-cytosinyl),2-(1-guanyl)ethane cross-...

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Main Authors: Penketh, Philip G., Baumann, Raymond P., Ishiguro, Kimiko, Shyam, Krishnamurthy, Seow, Helen A., Sartorelli, Alan C.
格式: Artigo
語言:Inglês
出版: 2008
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2888535/
https://ncbi.nlm.nih.gov/pubmed/18479747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.leukres.2008.03.005
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