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Lethality to leukemia cell lines of DNA interstrand cross-links generated by Cloretazine derived alkylating species
Cloretazine [1, 2-bis(methylsulfonyl)-1-(2-chloroethyl)-2-[(methylamino)carbonyl]-hydrazine; VNP40101M; 101M] is a relatively new prodrug with activity in elderly acute myelogenous leukemia patients. Its therapeutic action is due largely to the production of 1-(3-cytosinyl),2-(1-guanyl)ethane cross-...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2888535/ https://ncbi.nlm.nih.gov/pubmed/18479747 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.leukres.2008.03.005 |
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