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Expression of O(6)-Methylguanine-DNA Methyltransferase Examined by Alkyl-Transfer Assays, Methylation-Specific PCR and Western Blots in Tumors and Matched Normal Tissue
The tumor selectivity of alkylating agents that produce guanine O(6)-chloroethyl (laromustine and carmustine) and O(6)-methyl (temozolomide) lesions, depends upon O(6)-methylguanine-DNA methyltransferase (MGMT) activity being lower in tumor than in host tissue. Despite the established role of MGMT a...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3740405/ https://ncbi.nlm.nih.gov/pubmed/23946891 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4236/jct.2013.44103 |
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