載入...

Expression of O(6)-Methylguanine-DNA Methyltransferase Examined by Alkyl-Transfer Assays, Methylation-Specific PCR and Western Blots in Tumors and Matched Normal Tissue

The tumor selectivity of alkylating agents that produce guanine O(6)-chloroethyl (laromustine and carmustine) and O(6)-methyl (temozolomide) lesions, depends upon O(6)-methylguanine-DNA methyltransferase (MGMT) activity being lower in tumor than in host tissue. Despite the established role of MGMT a...

全面介紹

Na minha lista:
書目詳細資料
Main Authors: Ishiguro, Kimiko, Shyam, Krishnamurthy, Penketh, Philip G., Baumann, Raymond P., Sartorelli, Alan C., Rutherford, Thomas J., Ratner, Elena S.
格式: Artigo
語言:Inglês
出版: 2013
主題:
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3740405/
https://ncbi.nlm.nih.gov/pubmed/23946891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4236/jct.2013.44103
標簽: 添加標簽
沒有標簽, 成為第一個標記此記錄!