Загрузка...
Expression of O(6)-Methylguanine-DNA Methyltransferase Examined by Alkyl-Transfer Assays, Methylation-Specific PCR and Western Blots in Tumors and Matched Normal Tissue
The tumor selectivity of alkylating agents that produce guanine O(6)-chloroethyl (laromustine and carmustine) and O(6)-methyl (temozolomide) lesions, depends upon O(6)-methylguanine-DNA methyltransferase (MGMT) activity being lower in tumor than in host tissue. Despite the established role of MGMT a...
Сохранить в:
| Главные авторы: | , , , , , , |
|---|---|
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2013
|
| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3740405/ https://ncbi.nlm.nih.gov/pubmed/23946891 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4236/jct.2013.44103 |
| Метки: |
Добавить метку
Нет меток, Требуется 1-ая метка записи!
|