1,2-Bis(methylsulfonyl)-1-(2-chloroethyl)-2-[[1-(4-nitrophenyl)ethoxy]carbonyl]hydrazine (KS119): a Cytotoxic Prodrug with Two Stable Conformations Differing in Biological and Physical Properties

The anticancer prodrug 1,2-bis(methylsulfonyl)-1-(2-chloroethyl)-2-[[1-(4-nitrophenyl)ethoxy]carbonyl]hydrazine (KS119) selectively releases a short-lived cytotoxin following enzymatic reduction in hypoxic environments found in solid tumors. KS119, in addition to two enantiomers, has two stable atro...

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Detalhes bibliográficos
Main Authors: Penketh, Philip G., Baumann, Raymond P., Shyam, Krishnamurthy, Williamson, Hugh S., Ishiguro, Kimiko, Zhu, Rui, Eriksson, Emma S. E., Eriksson, Leif A., Sartorelli, Alan C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3171514/
https://ncbi.nlm.nih.gov/pubmed/21777394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1747-0285.2011.01193.x
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