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Transcriptional inhibitors identified in a 160,000-compound small molecule DUX4-viability screen

FSHD is a genetically dominant currently untreatable muscular dystrophy. It is caused by mutations that enable expression of the normally silent DUX4 gene, which encodes a pathogenic transcription factor. A screen based on Tet-on DUX4-induced mouse myoblast death previously uncovered compounds from...

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Detalhes bibliográficos
Publicado no:J Biomol Screen
Main Authors: Choi, Si Ho, Bosnakovski, Darko, Strasser, Jessica M., Toso, Erik A., Walters, Michael A., Kyba, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5501317/
https://ncbi.nlm.nih.gov/pubmed/27245141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1087057116651868
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