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Transcriptional inhibitors identified in a 160,000-compound small molecule DUX4-viability screen
FSHD is a genetically dominant currently untreatable muscular dystrophy. It is caused by mutations that enable expression of the normally silent DUX4 gene, which encodes a pathogenic transcription factor. A screen based on Tet-on DUX4-induced mouse myoblast death previously uncovered compounds from...
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| Gepubliceerd in: | J Biomol Screen |
|---|---|
| Hoofdauteurs: | , , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
2016
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5501317/ https://ncbi.nlm.nih.gov/pubmed/27245141 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1087057116651868 |
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