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High-throughput screening identifies inhibitors of DUX4-induced myoblast toxicity
BACKGROUND: Facioscapulohumeral muscular dystrophy (FSHD) is caused by epigenetic alterations at the D4Z4 macrosatellite repeat locus on chromosome 4, resulting in inappropriate expression of the DUX4 protein. The DUX4 protein is therefore the primary molecular target for therapeutic intervention. M...
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| Hoofdauteurs: | , , , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
BioMed Central
2014
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3914678/ https://ncbi.nlm.nih.gov/pubmed/24484587 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2044-5040-4-4 |
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