A novel P300 inhibitor reverses DUX4-mediated global histone H3 hyperacetylation, target gene expression, and cell death

Facioscapulohumeral muscular dystrophy (FSHD) results from mutations causing overexpression of the transcription factor, DUX4, which interacts with the histone acetyltransferases, EP300 and CBP. We describe the activity of a new spirocyclic EP300/CBP inhibitor, iP300w, which inhibits the cytotoxicit...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Sci Adv
Main Authors: Bosnakovski, Darko, da Silva, Meiricris T., Sunny, Sithara T., Ener, Elizabeth T., Toso, Erik A., Yuan, Ce, Cui, Ziyou, Walters, Michael A., Jadhav, Ajit, Kyba, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for the Advancement of Science 2019
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6739093/
https://ncbi.nlm.nih.gov/pubmed/31535023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aaw7781
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados