DUX4 recruits p300/CBP through its C-terminus and induces global H3K27 acetylation changes

Ectopic expression of the double homeodomain transcription factor DUX4 causes facioscapulohumeral muscular dystrophy (FSHD). Mechanisms of action of DUX4 are currently unknown. Using immortalized human myoblasts with a titratable DUX4 transgene, we identify by mass spectrometry an interaction betwee...

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Bibliografiska uppgifter
I publikationen:Nucleic Acids Res
Huvudupphovsmän: Choi, Si Ho, Gearhart, Micah D., Cui, Ziyou, Bosnakovski, Darko, Kim, Minjee, Schennum, Natalie, Kyba, Michael
Materialtyp: Artigo
Språk:Inglês
Publicerad: Oxford University Press 2016
Ämnen:
Gene regulation, Chromatin and Epigenetics
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4914088/
https://ncbi.nlm.nih.gov/pubmed/26951377
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw141
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