DUX4 recruits p300/CBP through its C-terminus and induces global H3K27 acetylation changes

Ectopic expression of the double homeodomain transcription factor DUX4 causes facioscapulohumeral muscular dystrophy (FSHD). Mechanisms of action of DUX4 are currently unknown. Using immortalized human myoblasts with a titratable DUX4 transgene, we identify by mass spectrometry an interaction betwee...

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Veröffentlicht in:Nucleic Acids Res
Hauptverfasser: Choi, Si Ho, Gearhart, Micah D., Cui, Ziyou, Bosnakovski, Darko, Kim, Minjee, Schennum, Natalie, Kyba, Michael
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2016
Schlagworte:
Gene regulation, Chromatin and Epigenetics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4914088/
https://ncbi.nlm.nih.gov/pubmed/26951377
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw141
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