DUX4 recruits p300/CBP through its C-terminus and induces global H3K27 acetylation changes

Ectopic expression of the double homeodomain transcription factor DUX4 causes facioscapulohumeral muscular dystrophy (FSHD). Mechanisms of action of DUX4 are currently unknown. Using immortalized human myoblasts with a titratable DUX4 transgene, we identify by mass spectrometry an interaction betwee...

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Bibliografske podrobnosti
izdano v:Nucleic Acids Res
Main Authors: Choi, Si Ho, Gearhart, Micah D., Cui, Ziyou, Bosnakovski, Darko, Kim, Minjee, Schennum, Natalie, Kyba, Michael
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2016
Teme:
Gene regulation, Chromatin and Epigenetics
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4914088/
https://ncbi.nlm.nih.gov/pubmed/26951377
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw141
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