A novel P300 inhibitor reverses DUX4-mediated global histone H3 hyperacetylation, target gene expression, and cell death

Facioscapulohumeral muscular dystrophy (FSHD) results from mutations causing overexpression of the transcription factor, DUX4, which interacts with the histone acetyltransferases, EP300 and CBP. We describe the activity of a new spirocyclic EP300/CBP inhibitor, iP300w, which inhibits the cytotoxicit...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Sci Adv
Prif Awduron: Bosnakovski, Darko, da Silva, Meiricris T., Sunny, Sithara T., Ener, Elizabeth T., Toso, Erik A., Yuan, Ce, Cui, Ziyou, Walters, Michael A., Jadhav, Ajit, Kyba, Michael
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Association for the Advancement of Science 2019
Pynciau:
Research Articles
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6739093/
https://ncbi.nlm.nih.gov/pubmed/31535023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aaw7781
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