An isogenetic myoblast expression screen identifies DUX4-mediated FSHD-associated molecular pathologies

Facioscapulohumeral muscular dystrophy (FSHD) is caused by an unusual deletion with neomorphic activity. This deletion derepresses genes in cis; however which candidate gene causes the FSHD phenotype, and through what mechanism, is unknown. We describe a novel genetic tool, inducible cassette exchan...

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Detalhes bibliográficos
Main Authors: Bosnakovski, Darko, Xu, Zhaohui, Ji Gang, Eun, Galindo, Cristi L, Liu, Mingju, Simsek, Tugba, Garner, Harold R, Agha-Mohammadi, Siamak, Tassin, Alexandra, Coppée, Frédérique, Belayew, Alexandra, Perlingeiro, Rita R, Kyba, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2572182/
https://ncbi.nlm.nih.gov/pubmed/18833193
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2008.201
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