DUX4c Is Up-Regulated in FSHD. It Induces the MYF5 Protein and Human Myoblast Proliferation

Facioscapulohumeral muscular dystrophy (FSHD) is a dominant disease linked to contractions of the D4Z4 repeat array in 4q35. We have previously identified a double homeobox gene (DUX4) within each D4Z4 unit that encodes a transcription factor expressed in FSHD but not control myoblasts. DUX4 and its...

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Main Authors: Ansseau, Eugénie, Laoudj-Chenivesse, Dalila, Marcowycz, Aline, Tassin, Alexandra, Vanderplanck, Céline, Sauvage, Sébastien, Barro, Marietta, Mahieu, Isabelle, Leroy, Axelle, Leclercq, India, Mainfroid, Véronique, Figlewicz, Denise, Mouly, Vincent, Butler-Browne, Gillian, Belayew, Alexandra, Coppée, Frédérique
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2009
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2759506/
https://ncbi.nlm.nih.gov/pubmed/19829708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0007482
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