Overexpression of the double homeodomain protein DUX4c interferes with myofibrillogenesis and induces clustering of myonuclei

BACKGROUND: Facioscapulohumeral muscular dystrophy (FSHD) is associated with DNA hypomethylation at the 4q35 D4Z4 repeat array. Both the causal gene DUX4 and its homolog DUX4c are induced. DUX4c is immunodetected in every myonucleus of proliferative cells, while DUX4 is present in only 1/1000 of myo...

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Detalhes bibliográficos
Publicado no:Skelet Muscle
Main Authors: Vanderplanck, Céline, Tassin, Alexandra, Ansseau, Eugénie, Charron, Sébastien, Wauters, Armelle, Lancelot, Céline, Vancutsem, Kelly, Laoudj-Chenivesse, Dalila, Belayew, Alexandra, Coppée, Frédérique
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5767009/
https://ncbi.nlm.nih.gov/pubmed/29329560
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13395-017-0148-4
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