Double-Stranded RNA-Dependent Protein Kinase-Dependent Apoptosis Induction by a Novel Small Compound

The interferon-induced, double-stranded RNA-dependent protein kinase (PKR) can play critical roles in inhibiting virus replication and inducing apoptosis. To develop new agents that may inhibit viral replication or induce apoptosis in cancer cells via the PKR signaling pathway, we screened a chemica...

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Detalhes bibliográficos
Main Authors: Hu, Wenxian, Hofstetter, Wayne, Wei, Xiaoli, Guo, Wei, Zhou, Yanbin, Pataer, Abujiang, Li, Hong, Fang, Bingliang, Swisher, Stephen G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Pharmacology and Experimental Therapeutics 2009
Assuntos:
Chemotherapy, Antibiotics, and Gene Therapy
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2658620/
https://ncbi.nlm.nih.gov/pubmed/19066342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.108.141754
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