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Induction of glutathione-dependent DNA double-strand breaks by the novel anticancer drug brostallicin
Brostallicin is a DNA minor groove binder in Phase II clinical trials. Here we show that brostallicin induces γ-H2AX nuclear foci that co-localize with 53BP1 and are dependent on glutathione, as demonstrated by inhibition of those γ-H2AX foci by L-buthionine sulfoximine (BSO). To differentiate brost...
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| 主要な著者: | , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2009
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2760303/ https://ncbi.nlm.nih.gov/pubmed/19584235 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-09-0320 |
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