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Transcription-coupled DNA Double-Strand Breaks Are Mediated via the Nucleotide Excision Repair and the Mre11-Rad50-Nbs1 Complex

The cellular activity of Yondelis (trabectedin, Ecteinascidin 743, Et743) is known to depend on transcription-coupled nucleotide excision repair (TCR). However, the subsequent cellular effects of Et743 are not fully understood. Here we show that Et743 induces both transcription- and replication-coup...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Guirouilh-Barbat, Josée, Redon, Christophe, Pommier, Yves
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The American Society for Cell Biology 2008
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2526702/
https://ncbi.nlm.nih.gov/pubmed/18632984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E08-02-0215
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