MCM8-9 complex promotes resection of double-strand break ends by MRE11-RAD50-NBS1 complex

MCM8-9 complex is required for homologous recombination (HR)-mediated repair of double-strand breaks (DSBs). Here we report that MCM8-9 is required for DNA resection by MRN (MRE11-RAD50-NBS1) at DSBs to generate ssDNA. MCM8-9 interacts with MRN and is required for the nuclease activity and stable as...

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Udgivet i:Nat Commun
Main Authors: Lee, Kyung Yong, Im, Jun-Sub, Shibata, Etsuko, Park, Jonghoon, Handa, Naofumi, Kowalczykowski, Stephen C., Dutta, Anindya
Format: Artigo
Sprog:Inglês
Udgivet: Nature Pub. Group 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4525285/
https://ncbi.nlm.nih.gov/pubmed/26215093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms8744
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