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MCM8-9 complex promotes resection of double-strand break ends by MRE11-RAD50-NBS1 complex
MCM8-9 complex is required for homologous recombination (HR)-mediated repair of double-strand breaks (DSBs). Here we report that MCM8-9 is required for DNA resection by MRN (MRE11-RAD50-NBS1) at DSBs to generate ssDNA. MCM8-9 interacts with MRN and is required for the nuclease activity and stable as...
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| Izdano u: | Nat Commun |
|---|---|
| Glavni autori: | , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Nature Pub. Group
2015
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4525285/ https://ncbi.nlm.nih.gov/pubmed/26215093 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms8744 |
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