Rad17 recruits the MRE11-RAD50-NBS1 complex to regulate the cellular response to DNA double-strand breaks

The MRE11-RAD50-NBS1 (MRN) complex is essential for the detection of DNA double-strand breaks (DSBs) and initiation of DNA damage signaling. Here, we show that Rad17, a replication checkpoint protein, is required for the early recruitment of the MRN complex to the DSB site that is independent of MDC...

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Autores principales: Wang, Qinhong, Goldstein, Michael, Alexander, Peter, Wakeman, Timothy P, Sun, Tao, Feng, Junjie, Lou, Zhenkun, Kastan, Michael B, Wang, Xiao-Fan
Formato: Artigo
Lenguaje:Inglês
Publicado: BlackWell Publishing Ltd 2014
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Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4194111/
https://ncbi.nlm.nih.gov/pubmed/24534091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/embj.201386064
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