MRE11-RAD50-NBS1 Complex Is Sufficient to Promote Transcription by RNA Polymerase II at Double-Strand Breaks by Melting DNA Ends

The MRE11-RAD50-NBS1 (MRN) complex supports the synthesis of damage-induced long non-coding RNA (dilncRNA) by RNA polymerase II (RNAPII) from DNA double-strand breaks (DSBs) by an unknown mechanism. Here, we show that recombinant human MRN and native RNAPII are sufficient to reconstitute a minimal f...

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Publicado no:Cell Rep
Main Authors: Sharma, Sheetal, Anand, Roopesh, Zhang, Xuzhu, Francia, Sofia, Michelini, Flavia, Galbiati, Alessandro, Williams, Hannah, Ronato, Daryl A., Masson, Jean-Yves, Rothenberg, Eli, Cejka, Petr, d’Adda di Fagagna, Fabrizio
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7788559/
https://ncbi.nlm.nih.gov/pubmed/33406426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2020.108565
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