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The Mre11-Nbs1 interface is essential for viability and tumor suppression

The Mre11 complex (Mre11, Rad50 and Nbs1) is integral to both DNA repair and ATM-dependent DNA damage signaling. All three Mre11 complex components are essential for viability at the cellular and organismal level. To delineate essential and non-essential Mre11 complex functions that are mediated by...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Kim, Jun Hyun, Grosbart, Malgorzata, Anand, Roopesh, Wyman, Claire, Cejka, Petr, Petrini, John H.J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5234850/
https://ncbi.nlm.nih.gov/pubmed/28076792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.12.035
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