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JNK-Deficiency Enhanced Oncolytic Vaccinia Virus Replication and Blocked Activation of Double-Stranded RNA-Dependent Protein Kinase
Vaccinia virus has recently been used as an expression vector for gene delivery and an oncolytic agent for cancer therapy. Although it has been established that interferon-induced double-stranded RNA (dsRNA)-activated protein kinase (PKR) and RNase L interfere with viral replication, little else is...
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| Main Authors: | , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2553758/ https://ncbi.nlm.nih.gov/pubmed/18535619 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cgt.2008.32 |
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