JNK-Deficiency Enhanced Oncolytic Vaccinia Virus Replication and Blocked Activation of Double-Stranded RNA-Dependent Protein Kinase

Vaccinia virus has recently been used as an expression vector for gene delivery and an oncolytic agent for cancer therapy. Although it has been established that interferon-induced double-stranded RNA (dsRNA)-activated protein kinase (PKR) and RNase L interfere with viral replication, little else is...

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Bibliografiske detaljer
Main Authors: Hu, Wenxian, Hofstetter, Wayne, Guo, Wei, Li, Hong, Pataer, Abujiang, Peng, Henry H., Guo, Z. Sheng, Bartlett, David L., Lin, Anning, Swisher, Stephen G., Fang, Bingliang
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2553758/
https://ncbi.nlm.nih.gov/pubmed/18535619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cgt.2008.32
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