Resultados da pesquisa - ((((eus j) OR (((eun a) OR (eun ha))))) OR (((eun a) OR (eun ha))u)) med chem

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1

Synthesis and biological evaluation of novel 3-(quinolin-4-ylamino)benzenesulfonamides as carbonic anhydrase isoforms I and II inhibitors

Synthesis and biological evaluation of novel 3-(quinolin-4-ylamino)benzenesulfonamides as carbonic anhydrase isoforms I and II inhibitors

Por Al-Sanea, Mohammad M., Elkamhawy, Ahmed, Paik, Sora, Bua, Silvia, Ha Lee, So, Abdelgawad, Mohamed A., Roh, Eun Joo, Eldehna, Wagdy M., Supuran, Claudiu T.
Publicado no J Enzyme Inhib Med Chem (2019)

“... the crucial role of the primary sulphfonamide group, as a zinc-binding group for CA inhibitory activity....”
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2

Molecular mechanism of inhibition of acid ceramidase by carmofur

Molecular mechanism of inhibition of acid ceramidase by carmofur

Por Dementiev, Alexey, Joachimiak, Andrzej, Nguyen, Ha, Gorelik, Alexei, Illes, Katalin, Shabani, Saman, Gelsomino, Michael, Ahn, Eun-Young Erin, Nagar, Bhushan, Doan, Ninh
Publicado no J Med Chem (2018)

“...Human acid ceramidase (AC) is a lysosomal cysteine amidase, which has received a great deal...”
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3

The carbonate analogues of 5′-halogenated resiniferatoxin as TRPV1 ligands

The carbonate analogues of 5′-halogenated resiniferatoxin as TRPV1 ligands

Por Lim, Kwang Su, Lee, Hobin, Kim, Sung Eun, Ha, Tae-Hwan, Ann, Jihyae, Son, Karam, Choi, Sun, Sun, Wei, Pearce, Larry V., DeAndrea-Lazarus, Ian A., Blumberg, Peter M., Lee, Jeewoo
Publicado no Eur J Med Chem (2013)

“...A series of carbonate analogues of 5′-halogenated RTX have been investigated in order to examine...”
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4

2-(3-Fluoro-4-methylsulfonylaminophenyl)propanamides as potent TRPV1 antagonists: Structure activity relationships of the 2-oxy pyridine C-region

2-(3-Fluoro-4-methylsulfonylaminophenyl)propanamides as potent TRPV1 antagonists: Structure activity relationships of the 2-oxy pyridine C-region

Por Thorat, Shivaji A., Kang, Dong Wook, Ryu, HyungChul, Kim, Myeong Seop, Kim, Ho Shin, Ann, Jihyae, Ha, Taehwan, Kim, Sung-Eun, Son, Karam, Choi, Sun, Blumberg, Peter M., Frank, Robert, Bahrenberg, Gregor, Schiene, Klaus, Christoph, Thomas, Lee, Jeewoo
Publicado no Eur J Med Chem (2013)

“... analysis of 53S using our hTRPVl homology model indicated that the A- and B-region 2-(3-fluoro-4...”
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5

TRPV1 antagonist with high analgesic efficacy: 2-Thio pyridine C-region analogues of 2-(3-fluoro-4-methylsulfonylaminophenyl) propanamides

TRPV1 antagonist with high analgesic efficacy: 2-Thio pyridine C-region analogues of 2-(3-fluoro-4-methylsulfonylaminophenyl) propanamides

Por Ha, Tae-Hwan, Ryu, HyungChul, Kim, Sung-Eun, Kim, Ho Shin, Ann, Jihyae, Tran, Phuong-Thao, Hoang, Van-Hai, Son, Karam, Cui, Minghua, Choi, Sun, Blumberg, Peter M., Frank, Robert, Bahrenberg, Gregor, Schiene, Klaus, Christoph, Thomas, Frormann, Sven, Lee, Jeewoo
Publicado no Bioorg Med Chem (2013)

“...A series of 2-thio pyridine C-region analogues of 2-(3-fluoro-4-methylsulfonylaminophenyl...”
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6

Pyridine C-region analogs of 2-(3-fluoro-4-methylsulfonylaminophenyl)propanamides as potent TRPV1 antagonists

Pyridine C-region analogs of 2-(3-fluoro-4-methylsulfonylaminophenyl)propanamides as potent TRPV1 antagonists

Por Ryu, HyungChul, Seo, Sejin, Lee, Jee-Young, Ha, Tae-Hwan, Lee, Sunho, Jung, Aeran, Ann, Jihyae, Kim, Sung-Eun, Yoon, Suyoung, Hong, Mannkyu, Blumberg, Peter M., Frank-Foltyn, Robert, Bahrenberg, Gregor, Schiene, Klaus, Stockhausen, Hannelore, Christoph, Thomas, Frormann, Sven, Lee, Jeewoo
Publicado no Eur J Med Chem (2015)

“...A series of pyridine derivatives in the C-region of N-((6-trifluoromethyl-pyridin-3-yl)methyl) 2-(3...”
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7

Structure–Activity Studies of Divin: An Inhibitor of Bacterial Cell Division

Structure–Activity Studies of Divin: An Inhibitor of Bacterial Cell Division

Por Zhou, Maoquan, Eun, Ye-Jin, Guzei, Ilia A., Weibel, Douglas B.
Publicado em 2013

“... of divin, a small molecule that blocks bacterial division by perturbing the assembly of proteins...”
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8

Simultaneous determination of methylcarbamate and ethylcarbamate in fermented foods and beverages by derivatization and GC-MS analysis

Simultaneous determination of methylcarbamate and ethylcarbamate in fermented foods and beverages by derivatization and GC-MS analysis

Por Shin, Ho-Sang, Yang, Eun-Young
Publicado em 2012

“... in fermented food and beverages. In order to estimate the risk for their exposure, a sensitive simultaneous...”
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9

Structure Activity Relationships of 1,4-Dihydropyridines That Act as Enhancers of the Vanilloid Receptor 1 (TRPV1)

Structure Activity Relationships of 1,4-Dihydropyridines That Act as Enhancers of the Vanilloid Receptor 1 (TRPV1)

Por Roh, Eun Joo, Keller, Jason M., Olah, Zoltan, Iadarola, Michael J., Jacobson, Kenneth A.
Publicado em 2008

“...Vanilloid agonists such as capsaicin activate ion flux through the TRPV1 channel, a heat...”
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10

CRISPR/dCas9-mediated biosensor for detection of tick-borne diseases

CRISPR/dCas9-mediated biosensor for detection of tick-borne diseases

Por Koo, Bonhan, Kim, Da-eun, Kweon, Jiyeon, Jin, Choong Eun, Kim, Sung-Han, Kim, Yongsub, Shin, Yong
Publicado no Sens Actuators B Chem (2018)

“... tool that utilizes CRISPR/dCas9-mediated biosensor that couples a nuclease inactivated Cas9 (dCas9...”
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11

Non-proteinogenic amino acids in the pThr-2 position of a pentamer peptide that confer high binding affinity for the polo box domain (PBD) of polo-like kinase 1 (Plk1)

Non-proteinogenic amino acids in the pThr-2 position of a pentamer peptide that confer high binding...

Por Qian, Wen-Jian, Park, Jung-Eun, Lee, Kyung S., Burke, Terrence R.
Publicado em 2012

“... pentapeptide, PLHSpT (1a) increases affinity. For certain analogues, approximately two orders-of-magnitude...”
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12

Effect of cinnamamides on atopic dermatitis through regulation of IL-4 in CD4(+) cells

Effect of cinnamamides on atopic dermatitis through regulation of IL-4 in CD4(+) cells

Por Choi, Eun-Ju, Ryu, Young Bae, Tang, Yujiao, Kim, Bo Ram, Lee, Woo Song, Debnath, Trishna, Fan, Meiqi, Kim, Eun-Kyung, Lee, Hyun-Su
Publicado no J Enzyme Inhib Med Chem (2019)

“...)-4, which plays a crucial role in preparing naïve clusters of differentiation (CD)4(+) T cells...”
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13

Synthesis and structure–activity relationship studies of tyrosine-based antagonists at the human P2X(7) receptor

Synthesis and structure–activity relationship studies of tyrosine-based antagonists at the human P2X(7) receptor

Por Lee, Ga Eun, Joshi, Bhalchandra V., Chen, Wangzhong, Jeong, Lak Shin, Moon, Hyung Ryong, Jacobson, Kenneth A., Kim, Yong-Chul
Publicado em 2007

“..., that is, uptake of a fluorescent dye (ethidium bromide) in stably transfected HEK293 cells and IL-1β release...”
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14

Synthesis, characterization and antineoplastic activity of bis-aziridinyl dimeric naphthoquinone - a novel class of compounds with potent activity against acute myeloid leukemia cells

Synthesis, characterization and antineoplastic activity of bis-aziridinyl dimeric naphthoquinone - a novel class of compounds with potent activity against acute myeloid leukemia cells

Por Carter-Cooper, Brandon A., Fletcher, Steven, Ferraris, Dana, Choi, Eun Yong, Kronfli, Dahlia, Dash, Smaraki, Truong, Phuc, Sausville, Edward A., Lapidus, Rena G., Emadi, Ashkan
Publicado no Bioorg Med Chem Lett (2016)

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15

(S)-4-Trimethylsilyl-3-butyn-2-ol as an auxiliary for stereocontrolled synthesis of salinosporamide analogs with modifications at positions C2 and C5

(S)-4-Trimethylsilyl-3-butyn-2-ol as an auxiliary for stereocontrolled synthesis of salinosporamide analogs with modifications at positions C2 and C5

Por Blasdel, Landy K., Lee, DongEun, Sun, Binyuan, Myers, Andrew G.
Publicado em 2013

“...Analogs of salinsporamide A with variations of the C2 and C5 substituents are prepared in 8–10...”
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16

Effects on Polo-like Kinase 1 Polo-box Domain Binding Affinities of Peptides Incurred by Structural Variation at the Phosphoamino Acid Position

Effects on Polo-like Kinase 1 Polo-box Domain Binding Affinities of Peptides Incurred by Structural Variation at the Phosphoamino Acid Position

Por Qian, Wenjian, Park, Jung-Eun, Liu, Fa, Lee, Kyung S., Burke, Terrence R.
Publicado em 2012

“... been little examination of pThr/pSer mimetics within a PBD context. Our current paper compares...”
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17

A novel nucleic acid amplification system based on nano-gap embedded active disk resonators

A novel nucleic acid amplification system based on nano-gap embedded active disk resonators

Por Lee, Eun Yeong, Kim, Yeseul, Koo, Bonhan, Noh, Geun Su, Lee, Hansuek, Shin, Yong
Publicado no Sens Actuators B Chem (2020)

“... signal. We here describe a novel nucleic acid amplification method based on a whispering gallery mode...”
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18

OGA inhibition by GlcNAc-selenazoline

OGA inhibition by GlcNAc-selenazoline

Por Kim, Eun Ju, Love, Dona C., Darout, Etzer, Abdo, Mohannad, Rempel, Brian, Withers, Stephen G., Rablen, Paul R., Hanover, John A., Knapp, Spencer
Publicado em 2010

“... only at the chalcogen atom (Se for S), is a much weaker inhibitor in a direct OGA assay. In human cells...”
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19

Inhibition of atherosclerosis-promoting microRNAs via targeted polyelectrolyte complex micelles

Inhibition of atherosclerosis-promoting microRNAs via targeted polyelectrolyte complex micelles

Por Kuo, Cheng-Hsiang, Leon, Lorraine, Chung, Eun Ji, Huang, Ru-Ting, Sontag, Timothy J., Reardon, Catherine A., Getz, Godfrey S., Tirrell, Matthew, Fang, Yun
Publicado no J Mater Chem B Mater Biol Med (2014)

“... of their ability to encapsulate charged nucleic acids forming a core by neutralizing their charge, while...”
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20

Synthesis and SAR of Thiazolylmethylphenyl Glucoside as Novel C-Aryl Glucoside SGLT2 Inhibitors

Synthesis and SAR of Thiazolylmethylphenyl Glucoside as Novel C-Aryl Glucoside SGLT2 Inhibitors

Por Song, Kwang-Seop, Lee, Suk Ho, Kim, Min Ju, Seo, Hee Jeong, Lee, Junwon, Lee, Sung-Han, Jung, Myung Eun, Son, Eun-Jung, Lee, MinWoo, Kim, Jeongmin, Lee, Jinhwa
Publicado em 2010

“... of these compounds have been further evaluated on a urinary glucose excretion test and the urine volumes excreted....”
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