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Synthesis and structure–activity relationship studies of tyrosine-based antagonists at the human P2X(7) receptor
Analogues of the P2X(7) receptor antagonist KN-62, modified at the piperazine and arylsulfonyl groups, were synthesized and assayed at the human P2X(7) receptor for inhibition of BzATP-induced effects, that is, uptake of a fluorescent dye (ethidium bromide) in stably transfected HEK293 cells and IL-...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2782582/ https://ncbi.nlm.nih.gov/pubmed/18078749 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2007.11.077 |
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