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Functionalized Congeners of Tyrosine-Based P2X(7) Receptor Antagonists: Probing Multiple Sites for Linking and Dimerization

Chemically funtionalized analogues of antagonists of the P2X(7) receptor, an ATP-gated cation channel, were synthesized as tools for biophysical studies of the receptor. These functionalized congeners were intended for use in chemical conjugation with retention of biological potency. The antagonists...

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Publicat a:Bioconjug Chem
Autors principals: Chen, Wangzhong, Ravi, R. Gnana, Kertesy, Sylvia B., Dubyak, George R., Jacobson, Kenneth A.
Format: Artigo
Idioma:Inglês
Publicat: 2002
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5577561/
https://ncbi.nlm.nih.gov/pubmed/12236792
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