Synthesis and structure–activity relationship studies of tyrosine-based antagonists at the human P2X(7) receptor

Analogues of the P2X(7) receptor antagonist KN-62, modified at the piperazine and arylsulfonyl groups, were synthesized and assayed at the human P2X(7) receptor for inhibition of BzATP-induced effects, that is, uptake of a fluorescent dye (ethidium bromide) in stably transfected HEK293 cells and IL-...

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Autores principales: Lee, Ga Eun, Joshi, Bhalchandra V., Chen, Wangzhong, Jeong, Lak Shin, Moon, Hyung Ryong, Jacobson, Kenneth A., Kim, Yong-Chul
Formato: Artigo
Lenguaje:Inglês
Publicado: 2007
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2782582/
https://ncbi.nlm.nih.gov/pubmed/18078749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2007.11.077
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