Synthesis and SAR of Thiazolylmethylphenyl Glucoside as Novel C-Aryl Glucoside SGLT2 Inhibitors

[Image: see text] Novel C-aryl glucoside SGLT2 inhibitors containing the thiazole motif were designed and synthesized for biological evaluation. Among the compounds assayed, thiazole containing furanyl moiety 14v and thiophenyl moiety 14y demonstrated the best in vitro inhibitory activity against SG...

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Bibliographic Details
Main Authors: Song, Kwang-Seop, Lee, Suk Ho, Kim, Min Ju, Seo, Hee Jeong, Lee, Junwon, Lee, Sung-Han, Jung, Myung Eun, Son, Eun-Jung, Lee, MinWoo, Kim, Jeongmin, Lee, Jinhwa
Format: Artigo
Language:Inglês
Published: American Chemical Society 2010
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4018110/
https://ncbi.nlm.nih.gov/pubmed/24900297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml100256c
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