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Synthesis and SAR of Thiazolylmethylphenyl Glucoside as Novel C-Aryl Glucoside SGLT2 Inhibitors
[Image: see text] Novel C-aryl glucoside SGLT2 inhibitors containing the thiazole motif were designed and synthesized for biological evaluation. Among the compounds assayed, thiazole containing furanyl moiety 14v and thiophenyl moiety 14y demonstrated the best in vitro inhibitory activity against SG...
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| Hauptverfasser: | , , , , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Chemical Society
2010
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| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4018110/ https://ncbi.nlm.nih.gov/pubmed/24900297 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml100256c |
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