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Effects on Polo-like Kinase 1 Polo-box Domain Binding Affinities of Peptides Incurred by Structural Variation at the Phosphoamino Acid Position

Protein-protein interactions (PPIs) mediated by the polo-box domain (PBD) of polo-like kinase 1 (Plk1) serve important roles in cell proliferation. Critical elements in the high affinity recognition of peptides and proteins by PBD are derived from pThr/pSer-residues in the binding ligands. However,...

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שמור ב:
מידע ביבליוגרפי
Main Authors: Qian, Wenjian, Park, Jung-Eun, Liu, Fa, Lee, Kyung S., Burke, Terrence R.
פורמט: Artigo
שפה:Inglês
יצא לאור: 2012
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3462889/
https://ncbi.nlm.nih.gov/pubmed/22743087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2012.05.036
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