Identification of High Affinity Polo-like Kinase 1 (Plk1) Polo-box Domain Binding Peptides Using Oxime-based Diversification

In an effort to develop improved binding antagonists of the polo-like kinase 1 (Plk1) polo-box domain (PBD), we optimized interactions of the known high affinity 5-mer peptide, PLHSpT using oxime-based post-solid-phase peptide diversification of the N-terminal Pro residue. This allowed us to achieve...

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Main Authors: Liu, Fa, Park, Jung-Eun, Qian, Wen-Jian, Lim, Dan, Scharow, Andrej, Berg, Thorsten, Yaffe, Michael B., Lee, Kyung S., Burke, Terrence R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3355227/
https://ncbi.nlm.nih.gov/pubmed/22292814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb200469a
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