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Peptoid-Peptide Hybrid Ligands Targeting the Polo Box Domain of Polo-Like Kinase 1
We replaced the amino terminal Pro residue of the Plk1 polo box domain-binding 5-mer peptide (PLHSpT) with a library of N-alkyl-Gly “peptoids” and identified long-chain tethered phenyl moieties giving greater than two-orders-of-magnitude affinity enhancement. Further simplification by replacing the...
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| Pubblicato in: | Chembiochem |
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| Autori principali: | , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2012
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4536914/ https://ncbi.nlm.nih.gov/pubmed/22570300 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201200206 |
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