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Peptoid-Peptide Hybrid Ligands Targeting the Polo Box Domain of Polo-Like Kinase 1

We replaced the amino terminal Pro residue of the Plk1 polo box domain-binding 5-mer peptide (PLHSpT) with a library of N-alkyl-Gly “peptoids” and identified long-chain tethered phenyl moieties giving greater than two-orders-of-magnitude affinity enhancement. Further simplification by replacing the...

詳細記述

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書誌詳細
出版年:Chembiochem
主要な著者: Liu, Fa, Park, Jung-Eun, Qian, Wen-Jian, Lim, Dan, Scharow, Andrej, Berg, Thorsten, Yaffe, Michael B., Lee, Kyung S., Burke, Terrence R.
フォーマット: Artigo
言語:Inglês
出版事項: 2012
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4536914/
https://ncbi.nlm.nih.gov/pubmed/22570300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201200206
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